Home to the Zacchei family as early as the early 16th century, the palace was acquired around the middle of the 17th century by the Benedetti family, possibly of Lombard or Marche origin, who settled in Foligno in the 16th century. After settling in the palace, the Benedettis acquired other adjoining buildings in the years 1674-1675, thus expanding the original nucleus of their new home. The portal is surmounted by a projecting cornice and decorated with lively figured elements, among which a mask inserted in a crushed shell valve stands out. Above the cornice, the balcony is noteworthy, with a wrought-iron railing decorated with forged foil leaves and bronze knobs on the joint boards. The windows on the main floor have stone frames with the heraldic symbols of the Benedetti family (the sun, the stars, the flame). In the last quarter of the seventeenth century, with the purchase of the new living quarters, the family was able to add a second, larger courtyard, where in the eighteenth century a nymphaeum was set up with two portraits (Aeschylus; a young man) from the Roman period, probably pieces from a rich collection of antiquities belonging to the family. In fact, between the late seventeenth and early eighteenth centuries, the presence in the palace of a "cimeliarchium," perhaps located on the piano nobile, is documented to collect the antiquarian and numismatic collection started already in the early seventeenth century by Natalizio Benedetti (1559-1614), a city magistrate and lover of Roman culture.