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This Sixteenth-century building was once the residence of the Unti family, yet it is called the Crispo Palace because of the stone coat of arms of Tiberio Crispo in the ashlar corner. Tiberio Crispo was the son of Giovanni Battista Crispo from Tarquinia and of Silvia Ruffini, who became the concubine of the future Pope Paul III after being widowed, and he was known as a cardinal and papal legate for the Province of Umbria from 1545 to 1548. The reason for the presence of his coat of arms on this Palazzo is unknown, though it could be connected to the rearrangement of the square following the renovation of the town hall, which took place in the years of Tiberio Crispo’s mandate as papal legate in Umbria.